James R Schaeffer

Title: **James R. Schaeffer: Innovator in Analytical Chemistry Based in Penfield, NY**

Introduction

James R. Schaeffer is a distinguished inventor based in Penfield, NY, with a remarkable portfolio of 14 patents. His innovative contributions primarily focus on the development of dry analytical elements for medical assays, enhancing both existing technologies and introducing novel methods for sensitivity and accuracy in clinical testing.

Latest Patents

Among his latest patents, Schaeffer's work on the "Dry Analytical Element for Acetaminophen Assay" stands out. This invention utilizes a spectrophotometric assay to detect acetaminophen in aqueous fluids through a unique dry analytical element. The element features a support structure with multiple reagent layers that include a first enzyme, aryl acylamidase, which cleaves the amide bond of acetaminophen. This process generates p-aminophenol, which is then oxidized using a mild oxidizing agent. This reaction facilitates a coupling with a water-soluble agent to form a dye measurable at 670 nm. The assay is notably precise, accurate on serum and plasma samples, and minimizes significant interferences while allowing measurements over a broad dynamic range.

Another significant achievement includes his patent for "Dry Analytical Elements for the Determination of Protein." This invention enables the rapid and sensitive detection and quantification of protein in samples. The procedure employs a dye that reacts with protein and molybdate ions to produce a measurable spectral absorption change. Additionally, Schaeffer's patent introduces polymers that stabilize and enhance assay accuracy and compounds designed to reduce interference from bicarbonate.

Career Highlights

Throughout his career, James R. Schaeffer has worked with reputable companies in the field of biomedical research. Notably, he has been associated with Eastman Kodak Company and Ortho-Clinical Diagnostics, Inc., where he contributed to the advancement of analytical chemistry technologies. His innovative efforts have significantly impacted clinical diagnostics and research methodologies.

Collaborations

Schaeffer has collaborated with notable colleagues, including Robert F. Winterkorn and Harry Wayne Harris, whose collective expertise has enhanced the development and implementation of their groundbreaking technologies.

Conclusion

Overall, James R. Schaeffer's contributions to the field of analytical chemistry are marked by a strong focus on innovation and precision. His patents demonstrate a commitment to improving medical diagnostics through the development of advanced analytical elements. Schaeffer's work is crucial for enhancing the accuracy and efficiency of laboratory testing, underlining his status as a leading inventor in his field.