James R Hagman

Title: James R Hagman: Innovator in Biologically Active Analogs

Introduction

James R Hagman is a notable inventor based in Berkeley, CA (US). He has made significant contributions to the field of biochemistry, particularly in the development of biologically active analogs of adrenocorticotropic hormone (ACTH). His innovative work has implications for both research and clinical applications.

Latest Patents

Hagman holds a patent for "Biologically active analogs of ACTH and radioimmuno assay therefor." This patent describes a fully steroidogenically active analog of ACTH, which differs from natural ACTH by having phenylalanine replace tyrosine in the second position on the peptide chain, and norleucine replace methionine in the fourth position. The analog can be iodinated to yield [I]Tyr.sup.2 -Phe.sup.2,Nle.sup.4 -ACTH, which retains full steroidogenic activity. When labeled with iodine-125, this analog is useful for tracking steroidogenic processes and in radioimmunoassays for ACTH.

Career Highlights

Throughout his career, Hagman has focused on advancing the understanding of steroidogenesis and the development of related assays. His work has contributed to the broader field of endocrinology and has provided valuable tools for researchers and clinicians alike.

Collaborations

Hagman has collaborated with notable colleagues such as Janakiraman Ramachandran and Donald H Yamashiro. These collaborations have likely enriched his research and expanded the impact of his innovations.

Conclusion

James R Hagman is a distinguished inventor whose work on biologically active analogs of ACTH has made a significant impact in the field of biochemistry. His innovative contributions continue to influence research and clinical practices.