The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 15, 1983
Filed:
May. 12, 1981
Applicant:
Inventors:
Janakiraman Ramachandran, Palo Alto, CA (US);
Douglas I Buckley, San Francisco, CA (US);
Donald H Yamashiro, San Francisco, CA (US);
James R Hagman, Berkeley, CA (US);
Assignee:
Other;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N / ; G01N / ; C07C / ;
U.S. Cl.
CPC ...
424-11 ; 2601 / ; 424-9 ;
Abstract
A fully steroidogenically active analog of ACTH is disclosed. The analog differs from natural ACTH in that phenylalanine replaces tyrosine in the second position on the peptide chain; and norleucine replaces methionine in the fourth position on the peptide chain. The analog may be iodinated to yield [I]Tyr.sup.2 -Phe.sup.2,Nle.sup.4 -ACTH, which also retains full steroidogenic activity. When labeled with iodine-125 the analog is useful in following steroidogenic processes and also in radioimmunoassays for ACTH.