Location History:
- Williamsville, NY (US) (2001)
- Upper Holland, PA (US) (2002 - 2006)
- Holland, PA (US) (2005 - 2007)
- Arvada, CO (US) (2009)
Company Filing History:
5 out of 3,684 
1 out of 832,843 Years Active: 2001-2009
Title: James R. Burke: Innovator in Biopharmaceuticals
Introduction
James R. Burke, based in Holland, PA, is a notable inventor with a significant contribution to the field of biopharmaceuticals. With a total of five patents to his name, he has made impactful advancements, particularly in immunology and kinase activity measurement.
Latest Patents
Among his latest innovations are two pivotal patents:
1. **Assay for measuring IκB kinase activity and identifying IκB kinase modulators** - This patent focuses on a functional assay for IκB kinase (IKK), utilizing cells expressing an IκB-beta-lactamase fusion protein. The inventive assay screens for inhibitors of IKK, the proteasome, and ubiquitin ligase, which can be instrumental in treating NF-κB disorders, including various immune and inflammatory disorders. The invention also discusses cell lines, identified compounds, compositions containing such compounds, and methods for treating related disease states.
2. **Antibodies of the P2Y10 receptor useful in altering T lymphocyte function** - This patent details various modulators of P2Y10, including a specific antibody. The invention emphasizes methods for activating resting T lymphocytes and inhibiting the proliferation of activated T lymphocytes. It covers techniques for upregulating the transcription of P2Y10 mRNA and inducing its expression on the surface of T lymphocytes, along with pharmaceuticals for treating immune diseases.
Career Highlights
James R. Burke has spent a significant portion of his career at Bristol-Myers Squibb Company, where he continues to push the boundaries of biopharmaceutical research. His innovative work contributes to advancing therapeutic approaches that have the potential to enhance patient outcomes in various immune disorders.
Collaborations
Throughout his career, Burke has collaborated with esteemed colleagues, including Fred Christopher Zusi and Jacques Banville. These partnerships have fostered a dynamic research environment, leading to significant contributions in the field.
Conclusion
James R. Burke exemplifies the spirit of innovation within biopharmaceutical research. His patents reflect a commitment to addressing critical medical needs, particularly in the realm of immune and inflammatory disorders. Through his dedication and collaboration with fellow innovators, Burke continues to make strides that could greatly improve therapeutic strategies in the healthcare landscape.