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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 7250268 B1

PDFFull Text
Date of Patent:
Jul. 31, 2007

Filed:

Jul. 14, 2004

Assay for measuring iκb kinase activity and identifying iκb kinase modulators

Applicants:

James R. Burke, Holland, PA (US);

Shulin Wang, Monmouth Junction, NJ (US);

Inventors:

James R. Burke, Holland, PA (US);

Shulin Wang, Monmouth Junction, NJ (US);

Assignee:

Bristol-Myers Squibb Company, Princeton, NJ (US);

Attorney:

Brian C. Carey

Primary Examiner:

Sheridan Swope

Int. Cl.
CPC ...
C12Q 1/48 (2006.01); C12N 1/20 (2006.01); C12N 15/63 (2006.01); C12N 9/12 (2006.01); C12P 21/00 (2006.01); C12P 21/04 (2006.01); C07H 15/63 (2006.01);
U.S. Cl.
CPC ...
Abstract

The present invention relates to a functional assay for IκB kinase (IKK), the proteasome and ubiquitin ligase. Cells expressing an IκB-beta-lactamase fusion protein are used to screen for inhibitors of IKK, the proteasome and ubiquitin ligase. Inhibitors identified through the inventive assay are useful in the treatment of NF-κB disorders, such as immune and inflammatory disorders. The present invention also includes cell lines useful in assays of the invention, compounds identified by assays of the invention, compositions including such compounds and methods for the treatment of disease states.

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