Company Filing History:
Years Active: 2014-2017
Title: Innovations by James Patch
Introduction
James Patch is an accomplished inventor based in Cornwall on Hudson, NY (US). He has made significant contributions to the field of biochemistry, particularly in the purification of capsular polysaccharides. With a total of 3 patents to his name, his work has implications for vaccine development and other medical applications.
Latest Patents
James Patch's latest patents describe a shortened process for producing a solution containing substantially purified capsular polysaccharides from a cellular lysate broth. The process involves ultrafiltering and diafiltering a clarified lysate, followed by pH adjustment to less than 4.5, preferably about 3.5. This method precipitates at least 98% of the protein in the solution without significantly affecting polysaccharide yield. Additionally, after ultrafiltration, diafiltration, and acidification to a pH of less than 4.5, filtration using activated carbon precipitates at least 90% of the remaining protein while maintaining polysaccharide yield. The invention can purify various serotypes of S. pneumoniae, including 1, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, and 23F. In one embodiment, the cells are lysed using deoxycholate sodium (DOC), while in another, a non-animal derived lytic agent such as N-lauryl sarcosine sodium (NLS) is utilized.
Career Highlights
James Patch is currently associated with Wyeth, a prominent company in the pharmaceutical industry. His innovative work has contributed to advancements in the purification processes that are crucial for vaccine production and other medical applications.
Collaborations
James has collaborated with notable coworkers, including Yonghui Yuan and Mark Edward Ruppen, who have contributed to his research and development efforts.
Conclusion
James Patch's contributions to the field of biochemistry through his patents and collaborations highlight his role as an influential inventor. His work continues to impact the medical field, particularly in vaccine development and purification processes.