Location History:
- Palo Alto, CA (US) (1995)
- Stanford, CA (US) (1976 - 2019)
Company Filing History:
5 out of 5,309 
1 out of 1,860 
1 out of 5,452 
Years Active: 1976-2019
Title: The Innovations of James P. Collman
Introduction
James P. Collman is a distinguished inventor based in Stanford, California. He has made significant contributions to the field of biochemistry and stem cell research. With a total of 6 patents to his name, Collman's work focuses on mitochondrial inhibitors and their applications in various medical fields.
Latest Patents
One of Collman's latest patents involves mitochondrial inhibitors for use in culturing pluripotent stem cells. This patent discloses certain heterocyclic organic compounds that inhibit mitochondrial respiration while maintaining the pluripotency of human embryonic stem cells in culture, even in the presence of oxygen. Compounds such as substituted 5-aminotetrazoles are exemplified as reversible mitochondrial inhibitors. The pluripotency of the stem cells after culture is verified by the overexpression of pluripotent stem cell markers, including genes like NANOG, OCT4, and SURVIVIN after periods of culture in ambient oxygen. Another significant patent addresses reducing platelet activation, aggregation, and platelet-stimulated thrombosis or blood coagulation by inhibiting mitochondrial respiration in platelets. This discovery indicates that certain heterocyclic compounds can significantly reduce platelet functions, which can be beneficial in treating diseases mediated by high levels of platelet activation or aggregation.
Career Highlights
Collman has had a notable career, working with prestigious organizations such as Leland Stanford Junior University and Chevron Research Company. His research has paved the way for advancements in medical treatments and therapies.
Collaborations
Throughout his career, Collman has collaborated with esteemed colleagues, including Xumu Zhang and Erich S. Uffelman. These collaborations have contributed to the success and impact of his research.
Conclusion
James P. Collman's innovative work in mitochondrial inhibitors and stem cell research has made a significant impact in the field of biochemistry. His contributions continue to influence medical research and therapeutic applications.