The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 20, 2018
Filed:
Apr. 25, 2011
James P. Collman, Stanford, CA (US);
Paul Clifford Herrmann, Loma Linda, CA (US);
David Alvin Tyvoll, La Jolla, CA (US);
Richard Decreau, Cedex, FR;
Brian Stanley Bull, Loma Linda, CA (US);
Christopher Jeffrey Barile, San Carlos, CA (US);
James P. Collman, Stanford, CA (US);
Paul Clifford Herrmann, Loma Linda, CA (US);
David Alvin Tyvoll, La Jolla, CA (US);
Richard Decreau, Cedex, FR;
Brian Stanley Bull, Loma Linda, CA (US);
Christopher Jeffrey Barile, San Carlos, CA (US);
The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US);
Abstract
It has been discovered that inhibiting mitochondrial respiration in platelets reduces platelet activation or platelet aggregation. Certain heterocyclic compounds significantly reduced one or more platelet functions including clumping, sticking or platelet-stimulated clotting. Thus diseases or disorders mediated by inappropriately high levels of platelet activation or platelet aggregation can be treated by administering a therapeutically effective amount of a heterocyclic compound or nonheterocyclic mitochondrial inhibitor that significantly reduces one or more platelet functions including clumping, sticking or platelet-stimulated clotting, preferably in a reversible manner.