James L Doran

Title: The Innovative Journey of James L Doran

Introduction

James L Doran, an accomplished inventor based in Brentwood Bay, California, is known for his significant contributions to the field of biotechnology. With a total of two patents to his name, Doran has made remarkable strides in developing systems for genetic engineering that have practical applications in diagnostics and microbial technology.

Latest Patents

Doran's latest patents include a revolutionary invention titled "Bacterial fimbrial system for presentation of heterologous peptide sequences." This invention provides a comprehensive system that allows for the creation of recombinant agfA fimbrin genes and facilitates chromosomal gene replacements. By doing so, it enables the development of strains that carry recombinant agfA genes at the native position in the chromosome. An important embodiment of this invention is the expression of a model epitope, PT3, derived from the GP63 protein. Doran's research highlights the formation of recombinant agfA genes that encode PT3 fusion proteins, which are recombined at ten different sites throughout the agfA gene. The resulting fusions are expressed in thin aggregative fimbriae on the surface of bacterial cells. This innovative approach offers a flexible and stable means for presenting foreign epitopes in Enterobacteriaceae, contributing significantly to diagnostic methods.

In addition to this, Doran's patent includes methods and compositions that involve the agfA gene from Salmonella. This isolated nucleic acid molecule is essential for developing highly specific diagnostic assays for Salmonella and enteropathogenic bacteria within the Enterobacteriaceae family.

Career Highlights

Throughout his career, James L Doran has collaborated with various prominent institutions. He has contributed to the Innovation and Development Corporation, as well as the University of Victoria. His involvement with the University of Victoria Innovation and Development Corporation has furthered advancements in biotechnological research and applications.

Collaborations

Doran has worked alongside esteemed colleagues, including S Karen Collinson and William W Kay. These collaborations have played a crucial role in refining his innovative approaches and extending the impact of his research in the field of biotechnology.

Conclusion

James L Doran's journey as an inventor is marked by his dedication to advancing biotechnology through innovative solutions. With a focus on genetic engineering and diagnostic methods, his contributions continue to influence the field. As he builds upon his work, the implications of his inventions pave the way for future research and applications in biotechnology.