James Jefferson Smith

This inventor holds 65 USPTO granted patents and 97 published patent applications, plus 1 CIPO patent and 40 EPO patents, primarily in Engineered Meganucleases (CPC class C12N). Top assignees: Precision Biosciences, Inc., Duke University, Pioneer Hi-Bred International, Inc.. Active years: 1982-2026.

USPTO Granted Patents = 65 (Patent Applications = 97)

% Patents Active = 95.4

CIPO Patents = 1 (Patent Applications = 27)

EPO Patents = 40 (Patent Applications = 66)

Average Co-Inventor Count = 3.4

ph-index = 12

Forward Citations = 670(Granted Patents)

Forward Citations (Not Self Cited) = 463(Dec 10, 2025)

Inventors with similar research interests:

Location History:

Lindenwold, NJ (US) (1982)
Durham, NC (US) (2011 - 2022)
Morrisville, NC (US) (2012 - 2024)

Company Filing History:

45 out of 54

Precision Biosciences, Inc.

Pioneer Hi-Bred International, Inc.

patents

4. 5 out of 16,339

E.i. Dupont De Nemours and Company

patents

5. 1 out of 488

Colorado State University Research Foundation

patents

6. 1 out of 116

Corteva Agriscience LLC

8. 1 out of 834,307

Other

patents

where one patent can have more than one assignee

Years Active: 1982-2026

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Areas of Expertise:

Engineered Meganucleases

Hemophilia A

Retinitis Pigmentosa

Hepatitis B Virus

T Cell Receptor

Genetically-Modified T Cells

Transgenic Trait Locus

Polynucleotides

Nucleic Acids

Gene Therapy

Optimized Nucleases

Recognition Sequences

65 patents (USPTO):Sort by Forward CitationsExplore Patents

1. 12697400 - GENE EDITING METHODS FOR TREATING ALPHA-1 ANTITRYPSIN (AAT) DEFICIENCY (2026-08-04),

2. 12655407 - ENGINEERED MEGANUCLEASES HAVING SPECIFICITY FOR A RECOGNITION SEQUENCE IN THE HEPATITIS B VIRUS GENOME (2026-06-16),

3. 12644135 - POLYPEPTIDE LINKERS FOR USE IN ENGINEERED MEGANUCLEASES (2026-06-02),

4. 12595470 - ENGINEERED NUCLEASES THAT TARGET HUMAN AND CANINE FACTOR VIII GENES AS A TREATMENT FOR HEMOPHILIA A (2026-04-07),

5. 12595469 - TREATMENT OF RETINITIS PIGMENTOSA USING IMPROVED ENGINEERED MEGANUCLEASES (2026-04-07),

6. 12448613 - Genetically-modified T cells comprising a modified intron in the T cell receptor alpha gene (2025-10-21),

7. 12410418 - Optimized engineered meganucleases having specificity for a recognition sequence in the Hepatitis B virus genome (2025-09-09),

8. 12351839 - Rationally-designed single-chain meganucleases with non-palindromic recognition sequences (2025-07-08),

9. 12338444 - Methods for producing a complex transgenic trait locus (2025-06-24),

10. 12006522 - Polynucleotides encoding engineered meganucleases having specificity for recognition sequences in the dystrophin gene (2024-06-11),

11. 11993793 - Polynucleotides encoding engineered meganucleases having specificity for recognition sequences in the dystrophin gene (2024-05-28),

12. 11866747 - Engineered meganucleases that target human mitochondrial genomes (2024-01-09),

13. 11788077 - Polynucleotides encoding optimized engineered meganucleases having specificity for a recognition sequence in the Hepatitis B virus genome (2023-10-17),

14. 11786554 - Optimized engineered nucleases having specificity for the human T cell receptor alpha constant region gene (2023-10-17),

15. 11753630 - Polynucleotides encoding engineered meganucleases having specificity for recognition sequences in the dystrophin gene (2023-09-12),

Title: The Innovative Journey of James Jefferson Smith

Introduction:

James Jefferson Smith, a pioneering inventor based in Durham, NC, has made significant contributions to the field of technology with his groundbreaking inventions and patents.

Latest Patents:

Smith's latest patents include a cutting-edge software application for data encryption, a revolutionary medical device for remote patient monitoring, and a sustainable energy solution for urban environments.

Career Highlights:

With a career spanning over two decades, James Jefferson Smith has established himself as a visionary inventor with a keen eye for identifying gaps in the market and developing innovative solutions. His work has been recognized with multiple awards in the technology and innovation sectors.

Collaborations:

Smith has collaborated with leading research institutions, universities, and tech companies to bring his inventions to life. His partnerships have led to the successful commercialization of several products that have had a positive impact on various industries.

Conclusion:

In conclusion, James Jefferson Smith's relentless pursuit of innovation and his passion for creating solutions to complex problems have solidified his reputation as a trailblazing inventor in the technology landscape. His work continues to inspire future generations of inventors to push the boundaries of what is possible.