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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12351839 B1

PDFFull Text
Date of Patent:
Jul. 08, 2025

Filed:

Mar. 17, 2023

Rationally-designed single-chain meganucleases with non-palindromic recognition sequences

Applicant:

Precision Biosciences, Inc., Durham, NC (US);

Inventors:

James Jefferson Smith, Morrisville, NC (US);

Derek Jantz, Durham, NC (US);

Assignee:

Precision BioSciences, Inc., Durham, NC (US);

Attorney:

Womble Bond Dickinson (US) LLP

Primary Examiner:

Suzanne M Noakes

Assistant Examiner:

Jae W Lee

Int. Cl.
CPC ...
C12N 9/22 (2006.01); A61P 31/00 (2006.01); A61P 31/04 (2006.01); A61P 31/12 (2006.01); A61P 33/02 (2006.01); A61P 43/00 (2006.01); C12N 9/16 (2006.01); C12N 15/85 (2006.01); C12N 15/90 (2006.01);
U.S. Cl.
CPC ...
C12N 9/22 (2013.01); C12N 9/16 (2013.01); C12N 15/8509 (2013.01); C12N 15/902 (2013.01); C12N 15/907 (2013.01); C12N 2800/80 (2013.01); C12Y 301/00 (2013.01); C12Y 301/04 (2013.01);
Abstract

Disclosed are rationally-designed, non-naturally-occurring meganucleases in which a pair of enzyme subunits having specificity for different recognition sequence half-sites are joined into a single polypeptide to form a functional heterodimer with a non-palindromic recognition sequence. The invention also relates to methods of producing such meganucleases, and methods of producing recombinant nucleic acids and organisms using such meganucleases.

Find Patent Forward Citations

Smith, James. (2025). Rationally-designed single-chain meganucleases with non-palindromic recognition sequences (U.S. Patent No. 12351839). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12351839

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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