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For the Inventor, By the Inventor

Verona, WI, United States of America

James J Cali

This inventor holds 27 USPTO granted patents and 7 published patent applications and 19 EPO patents, primarily in Bioluminescent Detection. Top assignee: Promega Corporation. Active years: 2010-2026.

IDiyas Innovation Intelligence. (2026). Inventor Profile: James J Cali. Retrieved from https://idiyas.com/inventor/james-j-cali

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

USPTO Granted Patents = 27 

% Patents Active = 85.2

 

Average Co-Inventor Count = 6.7

ph-index = 5

Forward Citations = 144(Granted Patents)


Company Filing History:

goldMedal27 out of 417 
 
Promega Corporation
 patents

Years Active: 2010-2026

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Areas of Expertise:
Bioluminescent Detection
ATP Detection
Luminogenic Compounds
Luciferase Assays
Real-Time Monitoring
Nucleic Acid Modifying Reagents
Fluorogenic Probes
Cytochrome P450 Activity
Redox State Assays
Quinone-Masked Probes
Stabilized Formulations
Multifunctional Probes
27 patents (USPTO):Explore Patents
1. 12578336 - ATP detection (2026-03-17),
2. 12571031 - Nucleic acid modifying reagents and uses thereof (2026-03-10),
3. 12061202 - Compositions and methods for bioluminescent detection using multifunctional probes (2024-08-13),
4. 11857638 - Quinone-containing conjugates (2024-01-02),
5. 11214822 - Stabilized formulation for luminescent detection of luciferase and nucleoside phosphates (2022-01-04),
6. 11066692 - Real-time monitoring (2021-07-20),
7. 10745365 - Luminogenic and fluorogenic compounds and methods to detect molecules or conditions (2020-08-18),
8. 10501774 - Stabilized formulation for luminescent detection of luciferase and nucleoside phosphates (2019-12-10),
9. 10408819 - Luminescence-based methods and probes for measuring cytochrome P450 activity (2019-09-10),
10. 10077244 - Luminogenic and fluorogenic compounds and methods to detect molecules or conditions (2018-09-18),
11. 9951372 - Compounds and methods for assaying redox state of metabolically active cells and methods for measuring NAD(P)/NAD(P)H (2018-04-24),
12. 9790537 - Quinone-masked probes as labeling reagents for cell uptake measurements (2017-10-17),
13. 9631225 - Luciferase-based assays (2017-04-25),
14. 9574223 - Luminescence-based methods and probes for measuring cytochrome P450 activity (2017-02-21),
15. 9487814 - Stabilized formulation for luminescent detection of luciferase and nucleoside phosphates (2016-11-08),

Title: The Innovative Contributions of James J. Cali in Bioluminescent Detection

Introduction

James J. Cali, a prolific inventor based in Verona, Wisconsin, is known for his groundbreaking work in the field of bioluminescent detection. With a remarkable portfolio of 25 patents, Cali has made significant contributions to the development of innovative technologies that enhance the detection and quantification of biomolecules.

Latest Patents

Among his latest inventions, Cali has patented two notable innovations. The first is titled "Compositions and methods for bioluminescent detection using multifunctional probes." This invention describes materials and methods for conducting bioluminescent assays utilizing bifunctional probes. These probes are designed to bind biomolecules and generate a bioluminescent or fluorescent signal, which can be crucial for analyzing cellular processes associated with those biomolecules.

The second patent, "Quinone-containing conjugates," details a system where conjugates comprise a drug or probe, a cell binding agent, and a quinone-containing linker. This linker can be reduced intracellularly, triggering the release of the drug or probe. This innovative approach allows for the selective delivery of therapeutic agents to target sites, enabling local release of active substances where they are most needed.

Career Highlights

Cali's career is marked by his dedication to advancing scientific research and technology. He is currently affiliated with Promega Corporation, a leading company in the field of biotechnology, where he applies his expertise in the development of life sciences tools. His work has significantly impacted the functionality of assays that are essential for both academic research and applied sciences.

Collaborations

Throughout his career, James J. Cali has collaborated with notable colleagues, including Keith V. Wood and Erika Hawkins. These partnerships have enabled the sharing of knowledge and expertise, fostering an environment ripe for innovation and discovery in their respective fields.

Conclusion

James J. Cali stands out as an influential inventor in the realm of bioluminescent detection. His continuous efforts to develop novel technologies and methodologies play a crucial role in enhancing biomolecular research and applications. With an impressive number of patents to his name, Cali's work exemplifies the spirit of innovation and the impact that dedicated inventors can have in scientific advancement.

Profile summary based on public USPTO records.
Data Sources: USPTO Patent Grant XML, Patent Center, EPO & CIPO • Normalized by IDiyas Innovation Graph. Methodology & provenance architecturePlease report any incorrect information to [email protected]
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