The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 02, 2024
Filed:
Jul. 26, 2019
Applicant:
Promega Corporation, Madison, WI (US);
Inventors:
Wenhui Zhou, San Luis Obispo, CA (US);
Hui Wang, San Luis Obispo, CA (US);
James J. Cali, Verona, WI (US);
Sarah Duellman, Madison, WI (US);
Jolanta Vidugiriene, Madison, WI (US);
Natasha Karassina, Madison, WI (US);
Assignee:
PROMEGA CORPORATION, Madison, WI (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/122 (2006.01); C07D 417/12 (2006.01); C07K 16/30 (2006.01); A61P 35/00 (2006.01); A61K 47/68 (2017.01); G01N 33/58 (2006.01); A61K 49/00 (2006.01);
U.S. Cl.
CPC ...
A61K 47/6889 (2017.08); A61K 31/122 (2013.01); A61K 47/6891 (2017.08); A61K 49/0039 (2013.01); A61K 49/0043 (2013.01); A61K 49/0052 (2013.01); C07D 417/12 (2013.01); C07K 16/30 (2013.01); G01N 33/582 (2013.01);
Abstract
Conjugates comprise a drug or probe, a cell binding agent, and a quinone-containing linker. The quinone-containing linker may be reduced intracellularly to trigger release of the drug or probe. These conjugates may selectively deliver a drug or probe to a site of action of interest for local release of the active drug or probe.