Company Filing History:
3 out of 2,961 
1 out of 832,680 Years Active: 2002-2008
Title: James Hogle: Innovator in Protein Interaction Inhibition
Introduction
James Hogle is a notable inventor based in Newton, MA (US), recognized for his contributions to the field of protein interaction inhibition. With a total of 4 patents to his name, Hogle has made significant strides in the development of methods and compounds that target protein-processivity factor interactions.
Latest Patents
Hogle's latest patents include a structure-based approach to the design of inhibitors of protein-processivity factor interactions. This invention discloses a method for the structure-based identification and selection of inhibitors that prevent processivity factor binding to proteins. It provides a characterization of the protein/processivity factor interface and outlines methods for inhibiting this binding. One embodiment of the invention features a class of peptidomimetics that mimic helical portions of proteins. Additionally, the patent discusses methods for treating various diseases using these inhibitors.
Another significant patent by Hogle involves the oligomerization of hepatitis delta antigen. This invention relates to HDAg peptides, including mutants, derivatives, fragments, and fusion molecules. It encompasses coiled-coil oligomers, nucleic acid molecules, and vectors comprising HDAg nucleic acid molecules. The methods described are particularly useful for multivalent expression and association of binding moieties of HDAg fusion molecules.
Career Highlights
Throughout his career, James Hogle has worked with prestigious institutions, including Harvard College. His innovative work has contributed to advancements in the understanding and manipulation of protein interactions.
Collaborations
Hogle has collaborated with notable individuals in his field, including Harmon J Zuccola and Carl Elkin. These collaborations have likely enriched his research and development efforts.
Conclusion
James Hogle's work in the field of protein interaction inhibition showcases his innovative spirit and dedication to advancing scientific knowledge. His patents reflect a commitment to developing methods that could lead to significant medical advancements.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.