The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 17, 2008
Filed:
May. 12, 2000
Donald Coen, Medfield, MA (US);
James Hogle, Newton, MA (US);
Carl Elkin, Cambridge, MA (US);
Harmon J. Zuccola, Brookline, MA (US);
Kristie Grove Bridges, Maynard, MA (US);
Scott Lokey, Santa Cruz, CA (US);
Donald Coen, Medfield, MA (US);
James Hogle, Newton, MA (US);
Carl Elkin, Cambridge, MA (US);
Harmon J. Zuccola, Brookline, MA (US);
Kristie Grove Bridges, Maynard, MA (US);
Scott Lokey, Santa Cruz, CA (US);
President and Fellows of Harvard College, Cambridge, MA (US);
Abstract
A method for the structure-based identification and selection of inhibitors of processivity factor binding to protein is disclosed herein. Characterization of the protein/processivity factor interface is given. Methods for the structure-based inhibition of processivity factor binding to protein are also given. One embodiment includes a class of peptidomimetics that mimic helical portions of proteins. In addition, methods of treatment of various diseases are given, using the inhibitors of the invention.