Harmon J Zuccola

Title: Harmon J Zuccola: Innovator in Protein-Processivity Factor Interactions

Introduction

Harmon J Zuccola is a notable inventor based in Brookline, MA (US). He has made significant contributions to the field of biochemistry, particularly in the design of inhibitors for protein-processivity factor interactions. With a total of 2 patents, his work has implications for various medical treatments.

Latest Patents

Zuccola's latest patents include a structure-based approach to the design of inhibitors of protein-processivity factor interactions. This patent discloses methods for the structure-based identification and selection of inhibitors that prevent processivity factor binding to proteins. It characterizes the protein/processivity factor interface and presents methods for inhibition, including a class of peptidomimetics that mimic helical portions of proteins. Additionally, it outlines methods for treating various diseases using these inhibitors. Another significant patent involves the oligomerization of hepatitis delta antigen (HDAg). This invention relates to HDAg peptides, including mutants, derivatives, fragments, and fusion molecules. It also covers methods for multivalent expression and the association of binding moieties of HDAg fusion molecules, which are particularly useful for multivalent display.

Career Highlights

Zuccola is affiliated with Harvard College, where he has been able to leverage his research to advance the understanding of protein interactions. His innovative approaches have contributed to the development of new therapeutic strategies.

Collaborations

Throughout his career, Zuccola has collaborated with esteemed colleagues such as James Hogle and Carl Elkin. These partnerships have enhanced the scope and impact of his research.

Conclusion

Harmon J Zuccola's work exemplifies the intersection of innovation and practical application in the field of biochemistry. His patents reflect a commitment to advancing medical science through the design of effective inhibitors.