Location History:
- Farmingham, MA (US) (1999)
- Framingham, MA (US) (1986 - 2016)
Company Filing History:
16 out of 2,896 
1 out of 8,396 
Years Active: 1986-2016
Title: The Innovations of James F. Gusella
Introduction
James F. Gusella is a prominent inventor based in Framingham, MA (US). He has made significant contributions to the field of molecular biology, particularly in the area of mRNA splicing. With a total of 17 patents, his work has the potential to impact the treatment of genetic disorders.
Latest Patents
Gusella's latest patents focus on methods for altering mRNA splicing and treating familial dysautonomia. One of his notable inventions involves administering benzyladenine to alter the splicing of mRNA in cells. This invention aims to increase the ratio of wild type to misspliced forms of mRNA, which is crucial for individuals with a mutant gene. Additionally, he has developed methods for treating disorders associated with misspliced mRNA, such as Familial Dysautonomia and Neurofibromatosis 1, by using cytokinin compounds like kinetin. Another patent also explores similar methods using kinetin, benzyladenine, and tocotrienols.
Career Highlights
Throughout his career, Gusella has worked with esteemed organizations such as The General Hospital Corporation and the Massachusetts Institute of Technology. His research has been instrumental in advancing our understanding of genetic disorders and their treatments.
Collaborations
Gusella has collaborated with notable colleagues, including Susan A. Slaugenhaupt and Marcy E. MacDonald. These partnerships have further enriched his research and innovations in the field.
Conclusion
James F. Gusella's contributions to the field of molecular biology and his innovative patents demonstrate his commitment to improving treatments for genetic disorders. His work continues to inspire advancements in medical research and therapy.