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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 7737110 B1

PDFFull Text
Expired
Date of Patent:
Jun. 15, 2010

Filed:

Oct. 01, 2004

Methods for altering mrna splicing and treating familial dysautonomia and other mechanistically related disorders

Applicants:

Susan A. Slaugenhaupt, Hingham, MA (US);

James F. Gusella, Framingham, MA (US);

Inventors:

Susan A. Slaugenhaupt, Hingham, MA (US);

James F. Gusella, Framingham, MA (US);

Assignee:

The General Hospital Corporation, Boston, MA (US);

Attorneys:

Kenneth H. Sonnenfeld

Margaret B. Brivanlou

King & Spalding LLP

Primary Examiner:

Nancy Vogel

Assistant Examiner:

Catherine Hibbert

Int. Cl.
CPC ...
A61K 38/00 (2006.01); A01N 61/00 (2006.01); C12N 15/00 (2006.01); C12N 15/01 (2006.01); C07H 21/04 (2006.01);
U.S. Cl.
CPC ...
Abstract

This invention relates to methods for altering the splicing of mRNA in cells. In particular, this invention also relates to methods for increasing the ratio of wild type to misspliced forms of mRNA and corresponding encoded proteins in cells possessing a mutant gene encoding either the i) misspliced mRNA corresponding to the mutant protein or ii) a component in the splicing machinery responsible for processing the misspliced mRNA. In addition, this invention relates to treating individuals having a disorder associated with a misspliced mRNA, such as Familial Dysautonomia or Neurofibromatosis 1, by administering to such an individual a cytokinin such as kinetin.

Find Patent Forward Citations

Slaugenhaupt, Susan. (2010). Methods for altering mrna splicing and treating familial dysautonomia and other mechanistically related disorders (U.S. Patent No. 7737110). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/7737110

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