Company Filing History:
Years Active: 2004-2006
Title: Innovations by James Cassella in GABA-Modulatory Compounds
Introduction
James Cassella is an accomplished inventor based in Guilford, CT (US). He has made significant contributions to the field of pharmacology, particularly in the development of methods for screening GABA-modulatory compounds. With a total of 2 patents, his work focuses on enhancing cognitive and therapeutic properties of various compounds.
Latest Patents
Cassella's latest patents involve innovative methods for screening GABA-modulatory compounds for specified pharmacological activities. These methods are designed to assay compounds for cognitive enhancing properties, anxiolytic properties, hypnotic properties, or antidepressant properties. The processes include determining the in vitro efficacy and EC of the compounds at defined series of cloned GABA subtype receptors, which are composed of specific variants of α, β, and γ subunits. This approach allows for the development of an activity profile for each compound. Additionally, the binding affinities of the compounds at GABA receptors can also be determined. As an extra step, the in vivo effects of the compounds may be tested in animal models.
Career Highlights
James Cassella has been instrumental in advancing research at Neurogen Corporation. His work has contributed to the understanding of GABA-modulatory compounds and their potential therapeutic applications. His innovative methods have paved the way for further research in cognitive enhancement and anxiety treatment.
Collaborations
Some of his notable coworkers include John Tallman and Dorothy Gallager, who have collaborated with him on various projects at Neurogen Corporation.
Conclusion
James Cassella's contributions to the field of pharmacology through his innovative patents and research at Neurogen Corporation highlight his role as a significant inventor in the realm of GABA-modulatory compounds. His work continues to influence the development of new therapeutic strategies.