The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 18, 2004
Filed:
May. 05, 2000
John Tallman, New York, NY (US);
Dorothy Gallager, Columbus, MT (US);
Kenneth Shaw, Weston, CT (US);
Geoffrey White, Guilford, CT (US);
Marci Crandall, Middletown, CT (US);
James Cassella, Guilford, CT (US);
Lavanya Rajachandran, Wallingford, CT (US);
Pamela Albaugh, Clinton, CT (US);
Neurogen Corporation, Branford, CT (US);
Abstract
Methods are provided that are useful in assaying compounds for cognitive enhancing properties, anxiolytic properties, hypnotic properties, or antidepressant properties. These methods involve determining the in vitro efficacy and EC of the compounds at defined series of cloned GABA subtype receptors composed of specific variants of &agr;,&bgr;, and &ggr; subunits in order to develop and an activity profile for each compound. Optionally, the binding affinities of the compounds at GABA receptors are also determined. As an additional step the in vivo effects of the compounds may be tested in animal models.