Company Filing History:
2 out of 196 
1 out of 3,439 
Years Active: 2002-2006
Title: James A. Wilkins: Innovator in Multiple Sclerosis and Inflammatory Disease Treatments
Introduction
James A. Wilkins is a notable inventor based in Woodbridge, CT (US), recognized for his contributions to medical science through his innovative patents. With a total of 2 patents, he has made significant strides in the diagnosis and treatment of multiple sclerosis and inflammatory diseases.
Latest Patents
Wilkins' latest patents include groundbreaking work on modified myelin basic protein molecules. This invention provides compositions and methods for the clinical assessment, diagnosis, and treatment of multiple sclerosis. The compositions involve molecules related to the 21.5 kDa fetal isoform of human myelin basic protein, including nucleic acids and polypeptides. These nucleic acid molecules are essential for the efficient production of modified and unmodified 21.5 kDa myelin basic protein polypeptides, which are useful for assaying T cells for responsiveness to myelin basic protein epitopes. Additionally, the polypeptides serve as therapeutic agents that induce T cell responses, including apoptosis, to treat multiple sclerosis.
Another significant patent by Wilkins involves C5-specific antibodies for the treatment of inflammatory diseases. This patent discloses the use of anti-C5 antibodies, such as monoclonal antibodies, to treat glomerulonephritis (GN). The administration of these antibodies at low dosage levels has been shown to significantly reduce glomerular inflammation and other pathological conditions associated with GN. The patent also includes anti-C5 antibodies and anti-C5 antibody-encoding nucleic acid molecules, which are beneficial in treating GN and other inflammatory conditions involving pathological activation of the complement system.
Career Highlights
Throughout his career, James A. Wilkins has worked with prominent organizations, including Alexion Pharmaceuticals, Inc. and the National Institutes of Health, a component of the US Department of Health & Human Services. His work in these institutions has contributed to advancements in medical research and therapeutic development.
Collaborations
Wilkins has collaborated with esteemed colleagues, including Louis A. Matis and Eileen Elliott Mueller, further enhancing the impact of his research and innovations in the field.
Conclusion
James A. Wilkins stands out as an influential inventor whose work has significantly advanced the understanding and treatment of multiple sclerosis and inflammatory diseases. His innovative patents reflect a commitment to improving patient outcomes through scientific
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