Company Filing History:
Years Active: 2022
Title: Jakob Franke: Innovator in Terpene Indole Alkaloid Synthesis
Introduction
Jakob Franke is a notable inventor based in Hannover, Germany. He has made significant contributions to the field of chemistry, particularly in the synthesis of terpene indole alkaloids. His innovative work has implications for various applications in biotechnology and pharmaceuticals.
Latest Patents
Jakob Franke holds a patent for a method and means for manufacturing terpene indole alkaloids. The complex chemistry underlying the extensive transformations involved in terpene indole alkaloid synthesis makes the identification of the biosynthetic genes challenging. The present invention relates to methods for producing a terpene indole alkaloid derivative, comprising the steps of: (1) providing a terpene indole alkaloid; and (2) providing a first enzyme termed 'Precondylocarpine Acetate Synthase' (PAS) or a functional variant or homologue thereof; and/or a second enzyme termed 'Dehydroprecondylocarpine Acetate Synthase' (DPAS) or a functional variant or homologue thereof, and optionally providing further identified enzymes involved in this pathway. The invention also encompasses related kits, enzymes, expression vectors, host cells, and plants.
Career Highlights
Jakob Franke is associated with the John Innes Centre, where he conducts his research and development activities. His work has been instrumental in advancing the understanding of terpene indole alkaloid synthesis.
Collaborations
Jakob has collaborated with notable colleagues such as Sarah O'Connor and Lorenzo Caputi, contributing to the advancement of their shared research interests.
Conclusion
Jakob Franke's innovative contributions to the field of terpene indole alkaloid synthesis highlight his role as a leading inventor in the chemistry domain. His patent and collaborative efforts continue to influence advancements in biotechnology and pharmaceuticals.