Jacob Berger

Title: Jacob Berger: Innovator in Nucleic Acid Detection

Introduction

Jacob Berger is a prominent inventor based in San Diego, California. He has made significant contributions to the field of nucleic acid detection, holding a total of 15 patents. His innovative work focuses on developing assays that enhance the detection of target nucleic acids without the need for amplification.

Latest Patents

Among his latest patents is a groundbreaking nucleic acid-guided nuclease cascade assay. This assay can detect one or more target nucleic acids of interest without amplifying them. The technology utilizes signal amplification mechanisms that include nucleic acid-guided nucleases and guide RNAs (gRNAs) forming ribonucleoprotein complexes, along with blocked primer molecules, template molecules, polymerases, and reporter moieties. Another notable patent involves tuning cascade assay kinetics via molecular design. This patent describes compositions and methods that allow for controlling the reaction kinetics of the cascade assay by two orders of magnitude through the molecular design of one of the reaction components. This innovation enables quantification of target nucleic acids over a wide range of concentrations and can discriminate between extremely low copy numbers of target nucleic acids.

Career Highlights

Jacob has worked with notable organizations such as Vedabio, Inc. and the University of Illinois. His experience in these institutions has contributed to his expertise in the field of nucleic acid detection and assay development.

Collaborations

Jacob has collaborated with talented individuals, including Anurup Ganguli and Ariana Mostafa. Their combined efforts have further advanced the research and development of innovative detection methods.

Conclusion

Jacob Berger is a distinguished inventor whose work in nucleic acid detection has led to significant advancements in the field. His patents reflect a commitment to innovation and a deep understanding of molecular design.