J Denry Sato

Title: J Denry Sato: Innovator in Monoclonal Antibody Research

Introduction

J Denry Sato is a notable inventor based in Lake Placid, NY (US). He has made significant contributions to the field of biotechnology, particularly in the development of monoclonal antibodies. With a total of 2 patents, his work has advanced the understanding and application of hybridomas in medical research.

Latest Patents

Sato's latest patents include innovative methods for producing hybridomas that generate monoclonal antibodies specifically targeting the human EGF receptor. These antibodies are designed to compete with EGF for binding to the EGF receptor. The monoclonal antibodies bind to an epitope located between residues Ala-351 and Asp-364 of the EGF receptor, which remains stable under various conditions, including boiling and treatment with detergents or reducing agents. Additionally, he has developed a method for isolating hybridomas based on cholesterol auxotrophy of myeloma cells. This method has shown to be significantly more efficient in producing antigen-reactive hybridoma cells compared to traditional HAT medium.

Career Highlights

Sato is currently associated with the W. Alton Jones Cell Science Center Incorporated, where he continues to push the boundaries of research in cell science. His innovative approaches have garnered attention in the scientific community, contributing to advancements in therapeutic applications.

Collaborations

Some of his notable coworkers include Dianging Wu and Lihua Wang, who have collaborated with him on various research projects. Their combined expertise has further enhanced the impact of their work in the field.

Conclusion

J Denry Sato's contributions to monoclonal antibody research exemplify the importance of innovation in biotechnology. His patents and ongoing research continue to pave the way for new therapeutic strategies.