Company Filing History:
Years Active: 2014-2017
Title: Ivory Hills - Innovator in Oligonucleotide Delivery
Introduction
Ivory Hills is a prominent inventor based in Deerfield, MA (US). She has made significant contributions to the field of oligonucleotide delivery, holding a total of 5 patents. Her innovative work focuses on developing cationic lipids that enhance the efficacy and safety of drug delivery systems.
Latest Patents
One of her latest patents is titled "Cationic lipids for oligonucleotide delivery." This invention provides novel cationic lipids that can be combined with other lipid components, such as cholesterol and PEG-lipids, to form lipid nanoparticles with oligonucleotides. The objective of this invention is to create a cationic lipid scaffold that is susceptible to hydrolytic instability, which may lead to reduced liver residence times and decreased hepatocellular toxicity. The invention employs acetals and ketals to introduce a low pH sensitive chemical handle for degradation.
Another significant patent is "Low molecular weight cationic lipids for oligonucleotide delivery." This invention also focuses on novel cationic lipids that can be used in conjunction with other lipid components to form lipid nanoparticles. The aim is to provide a cationic lipid scaffold that demonstrates enhanced efficacy while minimizing liver toxicity due to lower lipid levels in the liver. This invention utilizes low molecular weight cationic lipids with one short lipid chain to improve the efficiency and tolerability of in vivo delivery of siRNA.
Career Highlights
Ivory Hills is currently associated with Sirna Therapeutics, Inc., where she continues to advance her research in the field of drug delivery. Her work has been instrumental in developing innovative solutions that address critical challenges in oligonucleotide therapies.
Collaborations
She collaborates with notable colleagues, including Steven L Colletti and Matthew G Stanton, to further enhance the impact of her research and inventions.
Conclusion
Ivory Hills is a trailblazer in the field of oligonucleotide delivery, with a focus on developing innovative cationic lipids that improve drug delivery systems. Her contributions are paving the way for advancements in therapeutic applications.