The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 06, 2017
Filed:
Jan. 19, 2011
Steven L. Colletti, Princeton Junction, NJ (US);
Zhengwu James Deng, Eagleville, PA (US);
Matthew G. Stanton, Marlton, NJ (US);
Weimin Wang, Churchville, PA (US);
Ivory Hills, Deerfield, MA (US);
Steven L. Colletti, Princeton Junction, NJ (US);
Zhengwu James Deng, Eagleville, PA (US);
Matthew G. Stanton, Marlton, NJ (US);
Weimin Wang, Churchville, PA (US);
Ivory Hills, Deerfield, MA (US);
SIRNA THERAPEUTICS, INC., Cambridge, MA (US);
Abstract
The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that is susceptible to hydrolytic instability that may translate into reduced liver residence times and reduced hepatocellular toxicity. The present invention employs acetals and ketals to provide a low pH sensitive chemical handle for degradation.