Location History:
- Fayetteville, NY (US) (1985 - 1991)
- Durham, CT (US) (1989 - 1997)
Company Filing History:
4 out of 3,684 
4 out of 637 
1 out of 36 Years Active: 1985-1997
Title: **The Innovative Mind of Ivo Monkovic**
Introduction
Ivo Monkovic, an accomplished inventor based in Durham, CT (US), holds a notable portfolio of 9 patents. His work is at the intersection of pharmacology and biotechnology, focusing on developing compounds that effectively address significant health issues.
Latest Patents
Monkovic's latest patents include groundbreaking research on dihydropyridine NPY antagonists: piperazine derivatives and bifunctional linking compounds. The first patent outlines a series of non-peptidergic antagonists of neuropeptide Y (NPY), showcasing the synthesis of piperazine and homopiperazine derivatives of 4-phenyl-1,4-dihydropyridines. These compounds are designed to counter NPY-induced feeding behavior, presenting opportunities for the development of effective anorexiant agents aimed at promoting weight loss and managing eating disorders.
Another significant patent details novel N-substituted hydrazine bifunctional compounds that allow for targeted drug delivery systems. This invention includes cytotoxic reagent conjugates and methods for their production, emphasizing their potential to selectively kill target cell populations in treating diseases, including cancers and autoimmune disorders. The innovative hydrazone bonds enable the release of cytotoxic agents in specific cellular environments, marking a significant advancement in targeted therapy.
Career Highlights
Monkovic has contributed his expertise to notable pharmaceutical companies, including Bristol-Myers Squibb Company and Bristol-Myers Company. His work in these acclaimed institutions reflects his commitment to advancing medical science through innovative research and development.
Collaborations
Throughout his career, Monkovic has collaborated with esteemed colleagues, including David Willner and Takushi Kaneko. These partnerships have further enriched his work, driving the development of innovative solutions in biomedical research.
Conclusion
Ivo Monkovic exemplifies the spirit of innovation in the pharmaceutical industry, with a strong focus on creating compounds that can significantly improve patient outcomes. His contributions through patents and collaborations continue to pave the way for advancements in medical treatments and therapies.