Ingo Focken

Title: Ingo Focken: Innovator in Multispecific Binding Proteins

Introduction

Ingo Focken is a notable inventor based in Hochheim, Germany. He has made significant contributions to the field of biotechnology, particularly in the development of multispecific binding proteins. With a total of nine patents to his name, Focken's work has advanced the understanding and application of binding proteins in various therapeutic contexts.

Latest Patents

Focken's latest patents include innovations such as multispecific binding proteins with mutant fab domains. These binding proteins comprise a VL region paired with a VH region, and a CH1 region paired with a CL region. The VL and VH regions feature opposite charged mutations to facilitate pairing, while the CH1 and CL regions include mutations to enhance pairing. Additionally, his patents describe binding proteins with engineered cysteine residues in the VH/VL pair to form disulfide bonds. Another significant patent involves multispecific antibodies that facilitate selective light chain pairing, achieved through the use of different dimerization domains for light chain pairing. These innovations also encompass nucleic acids encoding the binding proteins, expression vectors, host cells, pharmaceutical compositions, and methods of treatment.

Career Highlights

Throughout his career, Ingo Focken has worked with prominent companies in the biotechnology sector, including Sanofi and Pieris Pharmaceuticals GmbH. His experience in these organizations has allowed him to collaborate on groundbreaking research and development projects, further enhancing