The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 23, 2024
Filed:
Dec. 23, 2019
Sanofi, Paris, FR;
Marta Amaral, Frankfurt am Main, DE;
Christian Beil, Frankfurt am Main, DE;
Ingo Focken, Frankfurt am Main, DE;
Gerhard Hessler, Frankfurt am Main, DE;
Soraya Hoelper, Frankfurt am Main, DE;
Jennifer Jung, Frankfurt am Main, DE;
Christian Lange, Frankfurt am Main, DE;
Wulf-Dirk Leuschner, Frankfurt am Main, DE;
Ercole Rao, Frankfurt am Main, DE;
Garima Tiwari, Frankfurt am Main, DE;
Sandra Weil, Frankfurt am Main, DE;
SANOFI, Paris, FR;
Abstract
Binding proteins comprising a VL region paired with a VH region, and a CH1 region paired with a CL region, wherein the VL region and VH region comprise opposite charged mutations to facilitate pairing, and wherein the CH1 region and CL region comprise mutations to facilitate pairing, are provided. Binding proteins comprising one or more cysteine residues engineered into the VH/VL pair to form one or more disulfide bonds, are also provided. Multispecific binding proteins, nucleic acids encoding binding proteins and multispecific binding proteins, expression vectors, host cells, pharmaceutical composition and methods of treatment administering the binding proteins or multispecific binding proteins described herein are also provided.