Imre Juhász

Title: Imre Juhász: Innovator in Pharmaceutical Chemistry

Introduction

Imre Juhász is a prominent inventor located in Budapest, Hungary. He has made significant contributions to the field of pharmaceutical chemistry, holding a total of five patents, with innovations focusing on the preparation of treprostinil, a vital synthetic prostacyclin derivative.

Latest Patents

Among his latest inventions is a patented process for the preparation of treprostinil. Treprostinil is known for its thrombocyte aggregation inhibitory and vasodilatory properties, with potential administration routes including subcutaneous, intravenous, inhalable, and oral forms. The disclosed method not only details the synthesis of treprostinil but also its various forms, including amorphous, anhydrate, monohydrate, and polyhydrate salts. This methodology is significant as it establishes a robust and well-scalable process, particularly at the chiral center in the 3-hydroxyoctyl substituent formed later in synthesis.

Another noteworthy patent concerns the process for preparing polymorph form B of treprostinil diethanolamine salt. This invention outlines a systematic approach involving dissolving treprostinil in methanol, incorporating diethanolamine, and carefully controlling the crystallization process through a series of well-defined steps. This method ensures a reproducible outcome while achieving high purity and yield of treprostinil diethanolamine salt.

Career Highlights

Imre Juhász has been associated with reputable companies such as Chinoin Gyógyszer és Vegyészeti Termékek Gyára Zrt. and Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. His career has been marked by a dedication to innovation within the pharmaceutical industry, where he has leveraged his expertise to develop robust manufacturing processes for complex compounds.

Collaborations

Throughout his career, Juhász has collaborated with talented professionals, including Irén Hortobágyi and István Lászlófi. These collaborations have undoubtedly contributed to the sophistication of his inventions and the advancement of pharmaceutical innovations.

Conclusion

Imre Juhász stands out as an instrumental figure in the realm of pharmaceutical inventions, particularly for his work on treprostinil. His patented processes not only showcase his innovative approach but also offer significant contributions to the field, potentially improving therapeutic options for various medical conditions. As the pharmaceutical landscape continues to evolve, the importance of inventors like Juhász in driving innovation cannot be overstated.