The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 15, 2023
Filed:
Jul. 15, 2021
Chinoin Gyógyszer És Vegyészeti Termékek Gyára Zrt., Budapest, HU;
Imre Juhász, Budapest, HU;
Irén Hortobágyi, Budapest, HU;
Tamás Altsach, Budapest, HU;
István Lászlófi, Budapest, HU;
Ágnes Nagyné Borkó, Budapest, HU;
Imre Rozsumberszki, Budapest, HU;
Gábor Havasi, Budapest, HU;
Zsuzsanna Kardos, Budapest, HU;
Péter Buzder-Lantos, Budapest, HU;
CHINOIN GYÓGYSZER ÉS VEGYÉSZETI TERMÉKEK GYÁRA ZRT., Budapest, HU;
Abstract
Treprostinil is a synthetic prostacyclin derivative with thrombocyte aggregation inhibitory and vasodilatory activity. Treprostinil can be administered in subcutaneous, intravenous, inhalable, or oral forms. Disclosed is a method for the preparation of treprostinil of formula I and its amorphous form, anhydrate form, monohydrate form, and polyhydrate form salts with bases. In the disclosed method, the chiral center in the 3-hydroxyoctyl substituent is formed at the end of the synthesis, so that the method is robust and well scalable. Also disclosed are treprostinil intermediates and the preparation of the intermediates.