Company Filing History:
Years Active: 2014-2016
Title: Ilaria Nardini: Innovator in Plasma Protein Purification
Introduction
Ilaria Nardini is a prominent inventor based in Barga, Italy. She has made significant contributions to the field of biochemistry, particularly in the purification of plasma proteins. With a total of 2 patents, her work focuses on developing efficient and scalable processes for therapeutic applications.
Latest Patents
Nardini's latest patents include a process for highly selective purification of two plasma proteins: von Willebrand factor (vWF) and fibronectin (Fn). This invention describes a chromatographic purification process that allows for the production of highly purified vWF and Fn from a biological fraction enriched in these proteins. The method is designed to be easily scalable to an industrial level, utilizing a strong anionic exchange resin. The concentrates produced exhibit high specific activity and low contaminant protein content, making them particularly suitable for therapeutic use.
Another notable patent is the process for the preparation of a virus-inactivated FV concentrate starting from human plasma. This invention provides a simple and cost-effective method for purifying FV, which is scalable to industrial levels. The process involves two anion exchange chromatography steps, effectively separating FV from other plasma components while ensuring the safety of the final product through viral inactivation and removal steps. The resulting FV concentrate is stable when frozen at -20°C.
Career Highlights
Ilaria Nardini is currently associated with Kedrion S.p.a., a company known for its expertise in the production of plasma-derived therapies. Her work at Kedrion has been instrumental in advancing the field of plasma protein purification.
Collaborations
Throughout her career, Nardini has collaborated with notable colleagues, including Filippo Mori and Claudio Farina. These collaborations have contributed to the development and refinement of her innovative processes.
Conclusion
Ilaria Nardini's contributions to the field of plasma protein purification highlight her role as a leading inventor in biochemistry. Her innovative processes not only enhance the efficiency of protein purification but also ensure the safety and efficacy of therapeutic products.