Igor P Smirnov

Title: Igor P Smirnov: Innovator in MALDI Technology

Introduction

Igor P Smirnov is a notable inventor based in Brookline, MA (US). He has made significant contributions to the field of mass spectrometry, particularly in the development of MALDI (Matrix-Assisted Laser Desorption/Ionization) technology. With a total of 3 patents, his work has advanced the capabilities of molecular analysis.

Latest Patents

One of his latest patents is for a MALDI plate and process for making a MALDI plate. This invention features a sample plate that includes an electrically conductive substrate with a hydrophobic coating. The thickness and hydrophobic character of this coating can be modified, enhancing the performance of the sample plate for reproducible deposition and analysis by MALDI-MS and MALDI-MS/MS processes. Various coating substances, including synthetic waxes, lipids, and natural waxes, have been identified to optimize the performance of the sample plate. Additionally, metal polishes have been utilized to clean and regenerate plate surfaces, further improving the reproducibility of the analysis.

Another significant patent is a method and apparatus for determining the molecular weight of labile molecules. This mass spectrometer instrument is designed to analyze heavy biological molecules such as proteins, peptides, or DNA oligomers. The instrument features a MALDI ion source enclosed in a chamber that allows for controlled gas flow, which aids in stabilizing the produced ions. By operating the source at elevated laser energy and using a high repetition rate laser, the sensitivity of analysis and speed of data acquisition are significantly enhanced.

Career Highlights

Igor has worked with several prominent companies, including Perseptive Biosystems Inc. and MDS Inc. His experience in these organizations has contributed to his expertise in mass spectrometry and molecular analysis technologies.

Collaborations

Throughout his career, Igor has collaborated with notable professionals in the field, including Lawrence A Haff and Anatoli Verentchikov. These collaborations have further enriched his work and innovations in the area of MALDI technology.

Conclusion

Igor P Smirnov's contributions to the field of mass spectrometry, particularly through his innovative patents, have significantly advanced the capabilities of molecular analysis. His work continues to influence the scientific community and enhance the understanding of complex biological molecules.