Howard T Jacobs

Title: Howard T Jacobs: Innovator in Mitochondrial Research

Introduction

Howard T Jacobs is a notable inventor based in Tampere, Finland. He has made significant contributions to the field of mitochondrial research, particularly in the areas of oxidative phosphorylation and male infertility diagnostics. With a total of 2 patents, Jacobs has demonstrated a commitment to advancing scientific knowledge and medical applications.

Latest Patents

Jacobs' latest patents include groundbreaking inventions that address critical health issues. The first patent, titled "Alternative oxidase and uses thereof," presents a method for combating disorders affecting the mitochondrial oxidative phosphorylation system. This invention focuses on the allotopic expression of the cyanide-insensitive alternative oxidase (AOX) in human cells. The successful expression of AOX has been shown to confer remarkable cyanide resistance to mitochondrial substrate oxidation, alleviate oxidative stress, reduce apoptosis susceptibility, and mitigate metabolic acidosis. AOX is well tolerated when expressed throughout the organism, making it a valuable tool for limiting the adverse effects of respiratory chain deficiencies.

The second patent, "Method of diagnosing and screening for male infertility through mutations in POLG," introduces a novel diagnostic method for detecting infertility in males. This method focuses on identifying mutations in the POLG gene, which encodes mitochondrial DNA polymerase, in biological samples. The invention also explores the use of the mutant POLG gene as a predictive test for male infertility and its potential association with other pathological conditions related to infertility.

Career Highlights

Throughout his career, Howard T Jacobs has worked with various organizations, including Licentia Ltd. and the Institut National De La Santé Et De La Recherche Médicale. His work has significantly impacted the understanding of mitochondrial functions and their implications for human health.

Collaborations

Jacobs has collaborated with esteemed colleagues, including Pierre Jean Frederic Rustin and Emmanuel Philippe Dassa. These partnerships have further enriched his research and contributed to the advancement of mitochondrial science.

Conclusion

Howard T Jacobs is a distinguished inventor whose work in mitochondrial research has led to innovative solutions for health challenges. His patents reflect a deep understanding of complex biological systems and a commitment to improving human health outcomes.