The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 11, 2009
Filed:
Nov. 01, 2006
Pierre Jean Frederic Rustin, Paris, FR;
Howard T. Jacobs, Tampere, FI;
Emmanuel Philippe Dassa, Saint-Denis, FR;
Gerrit a J Hakkaart, Amsterdam, NL;
Daniel Jose Moreno Fernandez-ayala, Pozo Alcon, ES;
Pierre Jean Frederic Rustin, Paris, FR;
Howard T. Jacobs, Tampere, FI;
Emmanuel Philippe Dassa, Saint-Denis, FR;
Gerrit A J Hakkaart, Amsterdam, NL;
Daniel Jose Moreno Fernandez-Ayala, Pozo Alcon, ES;
Licentia Ltd., Helsinki, FI;
INSERM (Institut National de la Sante et de la Recherche Medicale), Paris, FR;
Abstract
The invention relates to a method for combating disorders affecting the mitochondrial oxidative phosphorylation system by allotopic expression of the cyanide-insensitive alternative oxidase (AOX) in human cells. The successful expression of AOX in human cells and inhas been shown to confer spectacular cyanide-resistance to mitochondrial substrate oxidation, alleviate oxidative stress, apoptosis susceptibility and metabolic acidosis. AOX is well tolerated when expressed ubiquitously in the whole organism. AOX expression is a valuable tool to limit the deleterious consequences of respiratory chain deficiency.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile