Location History:
- Chigasaki, JP (1984 - 1988)
- Kanagawa, JP (1991)
- Kawasaki, JP (1993 - 1996)
- Chigasaki-shi, Kanagawa-ken, JP (1998)
Company Filing History:
9 out of 1,929 
2 out of 832,843 Years Active: 1984-1998
Title: Innovator Hiroshiro Shibai: A Pioneer in Biotechnological Inventions
Introduction
Hiroshiro Shibai, an accomplished inventor based in Kawasaki, Japan, has made significant strides in the field of biotechnology. With a remarkable portfolio of 10 patents, his work primarily focuses on advancements that can transform medical treatments and cellular applications.
Latest Patents
Among his latest innovations is a groundbreaking polypeptide capable of differentiating and maturing malignant cells into normal cells. This physiologically active polypeptide, BUF-3, not only facilitates the differentiation of human leukemia cells but also accelerates the formation of erythroblasts. The polypeptide showcases a molecular weight of 16 ± 1 Kd as determined by SDS-electrophoresis in the presence of 1% mercaptoethanol, or 25 ± 1 Kd in its absence.
Additionally, Shibai has developed a modified microbially-produced cellulose gel that incorporates human epidermal cells. The gel is characterized by the modification of cellulose through the physical or chemical bonding of an animal cell adhesive protein and the substitution of hydrogen atoms with organic groups. This innovative gel serves as a valuable carrier for the mass culture of animal cells and as a medical cover for wounds.
Career Highlights
Throughout his career, Hiroshiro Shibai has collaborated with notable companies, including Ajinomoto Co., Ltd. His contributions have significantly enhanced the understanding and application of biotechnological processes in medical and cellular contexts.
Collaborations
Shibai has worked alongside talented colleagues in his field, including Yuzuru Eto and Satoshi Takano. Their collaborative efforts have led to remarkable advancements and innovations in biotechnology.
Conclusion
Hiroshiro Shibai stands out as a leading inventor whose work is paving the way for future innovations in biotechnology. With his dedication to creating effective solutions for medical challenges, Shibai's contributions will surely have a lasting impact on the industry.