Ajinomoto Co., Ltd.

Other

Hiroshiro Shibai

Yuzuru Eto

Takao Kida

Satoshi Takano

Shigeyoshi Miyashiro

Tsuyoshi Shiio

Yasunori Yokogawa

Kunihiko Watanabe

Koichi Ishii

Toshihiko Ando

Daisuke Ejima

Shigeru Yamanaka

Shigezo Udaka

Naoto Koyama

Masahiko Okunishi

Etsuro Ogata

Kazuo Hirayama

Itaru Kojima

Kazukiyo Onodera

Shigeru Shioya

Michio Takahashi

Hajimu Morioka

Asao Murai

Yasuo Komoda

Ryosaku Noumi

Makoto Shiozaki

Yasuo Totsuka

Kunio Shioda

Masayo Washitake

Tomoko Tsuji

Misako Takezawa

Takehiko Ishikawa

A physiologically active polypeptide, BUF-3, having the ability to differentiate and maturate human leukemia cells into normal cells and of accelerating the formation of erythroblasts is disclosed. The polypeptide has a molecular weight of 16.+-.1 Kd as determined by SDS-electrophoresis in the presence of 1% mercaptoethanol, or 25.+-.1 Kd, as determined by SDS-electrophoresis in the absence of mercaptoethanol.

Polypeptide capable of differentiating and maturing malignant cells into

Disclosed is a gel of microbially-produced cellulose, characterized in that the microbially-produced cellulose is modified by (1) physically or chemically bonding an animal cell adhesive protein to the cellulose, and/or (2) substituting hydrogen atoms of at least parts of hydroxyl groups of the cellulose with a positively or negatively charged organic group. This gel is valuable as a carrier for mass culture of animal cells or as a medical vulnerary cover.

Modified microbially-produced cellulose gel with human epidermal cells

Pharmaceutical compositions containing the polypeptides BUF-3, BUF-4 and BUF-5 have hypoglycemic activity. BUF-3 is a homodimer of monomer A shown in FIG. 1. The monomer has a molecular weight of 16.+-.1 kd. BUF-4 is a heterodimer of monomer A and monomer B (FIG. 2). These products can be produced by cell culture of malignant leukemia cells or by recombinant DNA engineering.

Method of reducing blood sugar levels using a hypoglycemic agent

A cleavage promoting agent comprising as an effective ingredient at least one of the polypeptides BUF-3, BUF-4 and BUF-5 is useful for the treatment of fertilized or unfertilized ova in order to promote cell division and improve reproduction efficiency.

Composition containing buf-3 and superoxide dismutase as a cell cleavage

The polypeptides BUF-4 and BUF-5 may be used to treat osteoporosis, cancer, and anemia, and pharmaceutical compositions containing BUF-4 and/or BUF-5 are disclosed.

Pharmaceutical composition of BUF-5 for treating anemia

An antimycotic agent having a high degree of antimicrobial activity towards Eumycetes and with a level of toxicity lower than that of heptaene antibiotic V-28-3 is disclosed. This compound is a methyl ester derivative of heptaene antibiotic V-28-3.

Heptaene V-28-3 antibiotic derivative

This invention relates to a human T or B cell line carrying at least one Ela human adenovirus 12-type gene or fragment thereof; said cell line being capable of spontaneously producing an immmunologically active substance. This invention also relates to a process for producing an immunologically active substance comprising culturing a human B- or T- cell line carrying at least one human Ela adenovirus 12-type gene or fragment thereof in a culture medium capable of supporting growth thereof for a period of time effective to attain a spontaneous production of the substance thereof.

Human T or B cell lines and a process for producing immunologically

This invention relates to an antitumor composition of anthracycline compounds bonded to hydrophilic polypeptides having a molecular weight between 10,000 and 15,000.

Anthracycline compounds bound to hydrophilic polypeptides

A streptothricin-group compound having the formula: ##STR1## in which R represents ##STR2## is disclosed along with methods for producing this compound and a microorganism useful in its production.

Streptothricin-group compounds

Mycophenolic acid is produced by aerobically culturing in a culture medium a mutant of the genus Penicillium capable of producing mycophenolic acid, said mutant being resistant to clofibrat, and recovering the mycophenolic acid which accumulates in the culture medium.

Method for production of mycophenolic acid by fermentation

Growing community of inventors

Kawasaki, Japan

Hiroshiro Shibai