Hiroshige Murase

Title: Innovations of Hiroshige Murase

Introduction

Hiroshige Murase is a notable inventor based in Hekinan, Japan. He has made significant contributions to the field of starch production, holding 2 patents that focus on innovative methods for creating starch granules and cationic starch compositions.

Latest Patents

Murase's latest patents include a method for producing starch granules suitable as an excipient for orally disintegrating tablets. This method involves fluidized bed granulation, where a starch paste is sprayed in small amounts while a β-starch is fluidized using an air-fluidized bed. The process includes fluidized bed drying at a temperature equal to or higher than the gelatinization temperature of the β-starch, resulting in starch granules with a high degree of gelatinization. These granules provide satisfactory oral disintegratability and breaking strength, eliminating the need for additional auxiliary excipients during tableting. His second patent focuses on a new cationic starch and cationic starch paste or slurry, characterized by a low cation equivalent value despite a high nitrogen content. This innovation is formed through substitution with quaternary ammonium salt or a tertiary amino group, maintaining a low solution viscosity while achieving a high molecular weight.

Career Highlights

Hiroshige Murase is associated with Japan Corn Starch Co., Ltd., where he has been instrumental in advancing starch technology. His work has contributed to the development of new materials that enhance the functionality of pharmaceutical products.

Collaborations

Murase has collaborated with notable colleagues, including Hideyuki Tanaka and Takahiro Kuno, to further his research and innovations in starch production.

Conclusion

Hiroshige Murase's contributions to starch technology through his patents reflect his commitment to innovation in the field. His work continues to influence the development of effective excipients for pharmaceutical applications.