Japan Corn Starch Co., Ltd

Hiroshige Murase

Hideyuki Tanaka

Toshiyuki Niwa

Toshio Uno

Masao Umezaki

Takahiro Kuno

Kyoko Kitamura

A method for producing starch granules suitable as an excipient for an orally disintegrating tablet. Fluidized bed granulation is performed by spraying a starch paste in small amounts while a &#x3b2;-starch is being fluidized using an air-fluidized bed. Subsequently, fluidized bed drying is performed at a temperature equal to or higher than the gelatinization temperature of the &#x3b2;-starch. This yields starch granules having a high degree of gelatinization in comparison with the amount of &#x3b1;-starch adhered to the &#x3b2;-starch by the spraying of the starch paste. These starch granules alone impart satisfactory oral disintegratability and breaking strength to the tablet. Accordingly, when used as an excipient during tableting of orally disintegrating tablets, other auxiliary excipients such as saccharides or crystalline cellulose need not be added.

Method for producing starch granules, and orally disinitegrating tablet

Disclosed herein is a new cationic starch and cationic starch paste or slurry. The starch paste or slurry has a low cation equivalent value despite its high nitrogen content and also has a low solution viscosity despite its high molecular weight. The cationic starch and cationic starch paste or slurry is formed by substitution with a one or both of quaternary ammonium salt or a tertiary amino group, characterized in that its nitrogen content (X) due to the quaternary ammonium salt and/or tertiary amino group is related to its cation equivalent value (Y) as defined below:

Cationic starch composition and process for making same

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Hekinan, Japan

Hiroshige Murase