Hiroo Imura

Title: Hiroo Imura: Innovator in Endothelin Receptor Research

Introduction

Hiroo Imura is a notable inventor based in Kyoto, Japan. He has made significant contributions to the field of biochemistry, particularly in the study of endothelin receptors. With a total of 7 patents to his name, Imura's work has advanced our understanding of these critical receptors.

Latest Patents

One of Imura's latest patents involves the human endothelin receptor. This patent details the DNA encoding an endothelin receptor, which is isolated from cDNA prepared from poly(A) RNA derived from human placenta. The invention includes an expression vector containing the DNA and a transformant that contains this expression vector. By culturing this transformant, an endothelin receptor is obtained. The receptor shown in SEQ ID NO: 1 exhibits a high affinity for endothelins 1 and 2, particularly for endothelin 1. Meanwhile, the receptor shown in SEQ ID NO: 2 has an affinity for endothelins 1, 2, and 3 without selectivity.

Career Highlights

Throughout his career, Hiroo Imura has worked with prominent companies in the pharmaceutical industry, including Shionogi & Company Limited. His research has been pivotal in the development of therapeutic applications related to endothelin receptors.

Collaborations

Imura has collaborated with esteemed colleagues such as Kazuwa Nakao and Shigetada Nakanishi. These partnerships have further enriched his research and contributed to the advancement of knowledge in his field.

Conclusion

Hiroo Imura's innovative work in endothelin receptor research has led to significant advancements in biochemistry. His contributions continue to influence the scientific community and pave the way for future discoveries.