Location History:
- Kamakura, JP (1988)
- Mobara, JP (1989 - 1997)
Company Filing History:
5 out of 1,037 
3 out of 348 
2 out of 4 Years Active: 1988-1997
Title: Hiroaki Shimada: Innovator in Recombinant DNA Technology
Introduction
Hiroaki Shimada is a prominent inventor based in Mobara, Japan. He has made significant contributions to the field of biotechnology, particularly in the area of recombinant DNA technology. With a total of 5 patents, his work has paved the way for advancements in protein production.
Latest Patents
Shimada's latest patents focus on the DNA base sequence containing regions involved in the production of proteins. One notable patent involves a neutral protease gene of Bacillus amyloliquefaciens, which includes essential regions such as the promoter region, ribosome binding region, secretion region, structural gene region, and terminator region. These regions are crucial for constructing recombinant DNA used for protein production by culturing host bacteria transformed with this DNA. For instance, the extracellular production of neutral protease can be significantly enhanced by culturing B. subtilis transformed with recombinant DNA that includes the neutral protease gene. Additionally, the residual extracellular protease activities of a Bacillus subtilis strain can be reduced by introducing a gene that stimulates extracellular protease levels into the strain's genomic DNA. This innovative approach allows for the efficient production and accumulation of desired proteins in the culture medium.
Career Highlights
Throughout his career, Hiroaki Shimada has worked with notable organizations such as the Agency of Industrial Science and Technology and the Ministry of International Trade and Industry. His expertise in biotechnology has led to significant advancements in the field, particularly in the development of methods for protein production.
Collaborations
Shimada has collaborated with esteemed colleagues, including Yoshio Furutani and Masaru Honjo. These collaborations have further enriched his research and contributed to the success of his innovative projects.
Conclusion
Hiroaki Shimada's contributions to recombinant DNA technology and protein production have established him as a key figure in biotechnology. His innovative patents and collaborations continue to influence the field, showcasing the importance of his work in advancing scientific knowledge and applications.