Hiroaki Sawamoto

Title: Hiroaki Sawamoto: Innovator in Artificial Nucleic Acids

Introduction

Hiroaki Sawamoto is a prominent inventor based in Osaka, Japan. He has made significant contributions to the field of artificial nucleic acids, holding a total of six patents. His work focuses on developing novel compounds that have potential applications in various scientific and medical fields.

Latest Patents

One of his latest patents is for a crosslinked artificial nucleic acid known as ALNA. This invention provides a novel bridged artificial nucleic acid and an oligomer containing the same as a monomer. Specifically, it includes a compound represented by a general formula (I) or salts thereof, as well as an oligonucleotide compound represented by a general formula (I′) or salts thereof. Another significant patent involves a bridged nucleic acid called GuNA, along with a method for producing the same and an intermediate compound. This method includes a step of reacting a compound represented by formula II with a reducing agent to cleave an oxazolidine ring fused to a cycle A'. The reducing agent can include phosphines, metal hydrides, or transition metal catalysts in the presence of hydrogen gas.

Career Highlights

Hiroaki Sawamoto has worked with notable organizations such as Mitsubishi Tanabe Pharma Corporation and Osaka University. His experience in these institutions has allowed him to advance his research and contribute to the scientific community significantly.

Collaborations

Some of his notable coworkers include Kunio Saruta and Norimitsu Hayashi. Their collaborative efforts have further enriched the research and development of artificial nucleic acids.

Conclusion

Hiroaki Sawamoto's innovative work in artificial nucleic acids showcases his dedication to advancing scientific knowledge and technology. His patents reflect a commitment to developing new compounds that could have a lasting impact on various fields.