Hiroaki Kinoh

Title: Hiroaki Kinoh: Innovator in Cell Fusogenic Vectors

Introduction

Hiroaki Kinoh is a prominent inventor based in Ibaraki, Japan. He has made significant contributions to the field of biotechnology, particularly in the development of innovative cell fusogenic vectors. With a total of 2 patents, his work focuses on modifying protease-dependent tropism to enhance therapeutic applications.

Latest Patents

Kinoh's latest patents revolve around the creation of cell fusogenic vectors that possess replicative abilities. These vectors are designed to have modified protease-dependent tropism. Specifically, he has developed M gene-deficient viral vectors that encode modified F proteins. The cleavage site of the F protein from paramyxovirus is altered to be cleaved by different proteases. In cells transfected with these vectors, the genomic RNA is replicated, allowing for cell fusogenic infection to spread to neighboring cells, contingent on the presence of other proteases. Notably, no viral particles are released during this process. The vectors encode F proteins that are cleaved by proteases with enhanced activity in cancer, demonstrating a cancer growth suppressive effect in vivo.

Career Highlights

Hiroaki Kinoh is associated with Dna Vec Research Inc., where he continues to push the boundaries of biotechnological innovations. His work has garnered attention for its potential applications in cancer treatment and gene therapy.

Collaborations

Kinoh collaborates with notable colleagues, including Makoto Inoue and Yasuji Ueda, who contribute to his research endeavors.

Conclusion

Hiroaki Kinoh's innovative work in the field of biotechnology, particularly in developing modified cell fusogenic vectors, showcases his commitment to advancing therapeutic solutions for cancer treatment. His contributions are paving the way for future breakthroughs in medical science.