The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 04, 2010
Filed:
Jun. 17, 2008
Hiroaki Kinoh, Ibaraki, JP;
Makoto Inoue, Ibaraki, JP;
Yasuji Ueda, Ibaraki, JP;
Akihiro Iida, Ibaraki, JP;
Mamoru Hasegawa, Ibaraki, JP;
Masanori Kobayashi, Shiga, JP;
Hiroaki Kinoh, Ibaraki, JP;
Makoto Inoue, Ibaraki, JP;
Yasuji Ueda, Ibaraki, JP;
Akihiro Iida, Ibaraki, JP;
Mamoru Hasegawa, Ibaraki, JP;
Masanori Kobayashi, Shiga, JP;
DNAVEC Research Inc., Ibaraki, JP;
Abstract
The present invention provides cell fusogenic vectors having replicative ability, whose protease-dependent tropism has been modified. M gene-deficient viral vectors encoding modified F proteins, in which the cleavage site of the F protein of paramyxovirus is modified to be cleaved by different proteases, were produced. In cells transfected with these vectors, the genomic RNA present in the vectors is replicated, and cell fusogenic infection spreads to neighboring cells depending on the presence of other proteases; however, no viral particles are released. The vectors of this invention, encoding the F proteins which are cleaved by proteases whose activity is enhanced in cancer, show cancer growth suppressive effect in vivo.