Location History:
- Nagoya, JP (1996 - 1997)
- Aichi-gun, JP (1998)
Company Filing History:
3 out of 1,139 
1 out of 5,207 
Years Active: 1996-1998
Title: The Innovations of Hidehiko Sugiyama
Introduction
Hidehiko Sugiyama is a notable inventor based in Nagoya, Japan. He has made significant contributions to the field of biotechnology, particularly in the detection of nucleic acids and the development of thermostable polypeptides. With a total of 3 patents to his name, Sugiyama's work has implications for various applications in molecular biology.
Latest Patents
One of Sugiyama's latest patents is a method of detecting nucleic acid. This method utilizes hybridization between the nucleic acid present on an immobilizing support and a complementary DNA probe. The DNA probe includes a hapten attached via a linker, which can be gibberellin or a gibberellin derivative. After hybridization, unreacted DNA probes are removed, and a labeled anti-hapten antibody binds with the DNA probe of the hybrid, allowing for the detection of the nucleic acid. This method achieves stable detecting sensitivity regardless of the label mixing ratio or the nucleotide sequence composition of the nucleic acid being tested.
Another significant patent involves a polypeptide possessing protein disulfide isomerase (PDI) activity. This highly thermostable polypeptide is characterized by its ability to catalyze disulfide exchange in proteins, primarily recognizing ribonuclease A as a substrate. It operates effectively at temperatures ranging from 20°C to 70°C and maintains stability at a pH value of 6 to 9. The polypeptide has a molecular weight of about 60,000 to 62,000, making it a novel enzyme active protein that can be used advantageously for the refolding reaction of certain proteins.
Career Highlights
Throughout his career, Hidehiko Sugiyama has worked with prominent companies such as Toyota Central R&D Labs, Inc. and Aisin Seiki Co., Ltd. His experience in these organizations has contributed to his expertise in the field of biotechnology and innovation.
Collaborations
Sugiyama has collaborated with notable colleagues, including Yukio Yamada and Osamu Asami. These partnerships have likely enhanced his research and development efforts, leading to impactful innovations.
Conclusion
Hidehiko Sugiyama's contributions to biotechnology through his patents and collaborations highlight his role as a significant inventor in the field. His work