Helene Le Buanec

Title: Helene Le Buanec: Innovator in Regulatory T Cell Research

Introduction

Helene Le Buanec is a prominent inventor based in Paris, France, known for her significant contributions to the field of immunology. She holds four patents that focus on the generation and therapeutic applications of regulatory T cells, which play a crucial role in the immune response.

Latest Patents

Her latest patents include innovative methods for the ex vivo generation of MHCII restricted CD4Foxp3 regulatory T cells and γδ Foxp3 regulatory T cells. The first patent outlines a method for generating and expanding these regulatory T cells, demonstrating optimal conditions for inducing Foxp3 expression in naive CD3+ CD4+ TCRαβ+ MHCII restricted T cells. This invention also details an experimental procedure to create autologous CD8+ T cell lines that can target tumor-antigen specific FOXP3 expressing T cells, which are essential for combating tumor cell immune evasion. The second patent focuses on the ex vivo generation of γδ Foxp3 regulatory T cells, detailing the induction of Foxp3+ expression in tumor-antigen specific CD4+ TCRγδ unrestricted T cells and the development of methods to expand these cells for therapeutic use.

Career Highlights

Helene has worked with esteemed organizations such as the National Institute of Health and Medical Research (Institut National De La Sante Et De La Recherche Medicale) and Medicine and Innovation (Medecine Et Innovation). Her work has significantly advanced the understanding of regulatory T cells and their potential therapeutic applications.

Collaborations

Throughout her career, Helene has collaborated with notable colleagues, including Daniel Zagury and Sophie Duchez, contributing to the advancement of research in her field.

Conclusion

Helene Le Buanec's innovative work in the field of regulatory T cells has paved the way for new therapeutic strategies in immunology. Her patents reflect her dedication to advancing medical science and improving patient outcomes.