The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 14, 2021
Filed:
Aug. 04, 2017
Inserm (Institut National DE LA Sante ET DE LA Recherche Medicale), Paris, FR;
Medecine ET Innovation, Paris, FR;
Universite Paris Diderot—paris 7, Paris, FR;
Centre National DE LA Recherche Scientifique (Cnrs), Paris, FR;
Daniel Zagury, Paris, FR;
Helene Le Buanec, Paris, FR;
Sophie Duchez, Paris, FR;
Valerie Schiavon, Paris, FR;
Armand Bensussan, Paris, FR;
INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERE MEDICALE), Paris, FR;
MEDECINE ET INNOVATION, Paris, FR;
UNIVERSITE DE PARIS, Paris, FR;
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), Paris, FR;
Abstract
The present invention relates to a method for ex vivo generating and expanding γδ Foxp3regulatory T cells, and therapeutic uses thereof. The inventors performed the induction of Foxp3+ expression in ex vivo human induced tumor-antigen specific CD4+ TCRγδ unrestricted T cells and the induction of autologous CD8-mediated T-cell responses against tumor-antigen specific FOXP3 expressing CD4+ TCRγδ unrestricted T cells. The inventors developed a method to ex vivo generated and expanded antigen specific Foxp3 expressing CD3+ TCRγδ+ unrestricted T cells, committed to exclusively exert regulatory activity, whichever culture condition of stimulation is. In particular, the present invention relates to a method for generating ex vivo γδ Foxp3+ regulatory T cells having the following phenotype: CD3+ TCRγδ+ Foxp3+.