Company Filing History:
Years Active: 2018-2019
Title: Helene L Cardasis: Innovator in Mass Spectrometry
Introduction
Helene L Cardasis is a prominent inventor based in Mountain View, CA (US). She has made significant contributions to the field of mass spectrometry, particularly in the characterization of biological molecules. With a total of 3 patents to her name, her work has advanced the understanding and application of mass spectrometric techniques.
Latest Patents
One of her latest patents is focused on methods for mass spectrometric based characterization of biological molecules. This patent discloses applications of ion-ion reaction chemistry, where proton transfer reactions combined with higher-collision-energy dissociation are utilized. These methods simplify complex mixture analysis of samples introduced into a mass spectrometer and improve resolution and sensitivity for analyzing large proteins exceeding 50 kDa. The techniques remove charge, reduce the collisional cross section, and enhance sequence coverage obtained.
Another significant patent by Cardasis is the automated determination of mass spectrometer collision energy. This invention establishes new dissociation parameters to determine the collision energy needed for a desired extent of dissociation for a given analyte precursor ion. The selection is based solely on the molecular weight and charge state of the analyte precursor ion. The methods enable control over the extent of dissociation through automated, real-time selection of collision energy in a precursor-dependent manner.
Career Highlights
Helene L Cardasis has built a successful career at Thermo Finnigan LLC, where she has been instrumental in developing innovative mass spectrometry techniques. Her expertise in the field has led to advancements that benefit researchers and industries relying on precise biological analysis.
Collaborations
Throughout her career, Cardasis has collaborated with notable colleagues, including William M McGee and Ping F Yip. These partnerships have fostered a collaborative environment that enhances the development of cutting-edge technologies in mass spectrometry.
Conclusion
Helene L Cardasis is a trailblazer in the field of mass spectrometry, with her innovative patents significantly impacting the analysis of biological molecules. Her contributions continue to shape the future of scientific research and technology.