The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 16, 2018
Filed:
Jan. 13, 2017
Applicant:
Thermo Finnigan Llc, San Jose, CA (US);
Inventors:
William M. McGee, Watertown, MA (US);
Helene L. Cardasis, Mountain View, CA (US);
Assignee:
Thermo Finnigan LLC, San Jose, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/68 (2006.01); H01J 49/00 (2006.01); B01D 59/44 (2006.01); H01J 49/16 (2006.01);
U.S. Cl.
CPC ...
G01N 33/6848 (2013.01); H01J 49/0031 (2013.01); H01J 49/0072 (2013.01); H01J 49/165 (2013.01);
Abstract
Applications of ion-ion reaction chemistry are disclosed in which proton transfer reactions (PTR) combined with higher-collision-energy dissociation (HCD) are used to (1) simplify complex mixture analysis of samples introduced into a mass spectrometer, and (2) improve resolution and sensitivity for the analysis of large proteins in excess of 50 kDa by removing charge, reducing the collisional cross section, and, in several cases, enhancing the sequence coverage obtained.