Helena L Palka-Hamblin

Title: Helena L Palka-Hamblin: Innovator in Protein Interaction Research

Introduction

Helena L Palka-Hamblin is a prominent inventor based in Chicago, IL (US). She has made significant contributions to the field of protein interaction research, particularly in understanding the mechanisms of receptor proteins in human breast tumor cell lines.

Latest Patents

Helena holds a patent for "DEP-1 receptor protein tyrosine phosphatase interacting proteins and related methods." This invention identifies proteins from human breast tumor cell lines, such as MDA-MB-231 and T-47D, that interact specifically with the substrate-trapping mutant form of Density Enhanced Phosphatase-1 (DEP-1). The patent includes isolated complexes comprising DEP-1 polypeptides in specific association with proteins like Met, Gab 1, or p120, which are identified as DEP-1 substrate polypeptides. Additionally, the patent discloses screening assays for agents that alter DEP-1 interaction with these substrate polypeptides, as well as methods for modifying biological signals in cells transduced via DEP-1 pathways. Helena has 1 patent to her name.

Career Highlights

Helena is affiliated with Cold Spring Harbor Laboratory, where she conducts her research. Her work has been instrumental in advancing the understanding of protein interactions and their implications in cancer biology.

Collaborations

One of her notable collaborators is Nicholas K Tonks, with whom she has worked on various research projects related to protein interactions.

Conclusion

Helena L Palka-Hamblin is a key figure in the field of protein interaction research, with her innovative work contributing to the understanding of cancer mechanisms. Her patent highlights the importance of DEP-1 interactions in biological processes, showcasing her impact on scientific research.